Nadia Radovini / en New cancer treatment slows aggressive neuroendocrine tumours: Study /news/new-cancer-treatment-slows-aggressive-neuroendocrine-tumours-study <span class="field field--name-title field--type-string field--label-hidden">New cancer treatment slows aggressive neuroendocrine tumours: Study</span> <div class="field field--name-field-featured-picture field--type-image field--label-hidden field__item"> <img loading="eager" srcset="/sites/default/files/styles/news_banner_370/public/2024-06/Simron-Singh_99-220424d-crop.jpg?h=81d682ee&amp;itok=19zYDIOx 370w, /sites/default/files/styles/news_banner_740/public/2024-06/Simron-Singh_99-220424d-crop.jpg?h=81d682ee&amp;itok=7X8cXPhL 740w, /sites/default/files/styles/news_banner_1110/public/2024-06/Simron-Singh_99-220424d-crop.jpg?h=81d682ee&amp;itok=GyEbGFAF 1110w" sizes="(min-width:1200px) 1110px, (max-width: 1199px) 80vw, (max-width: 767px) 90vw, (max-width: 575px) 95vw" width="740" height="494" src="/sites/default/files/styles/news_banner_370/public/2024-06/Simron-Singh_99-220424d-crop.jpg?h=81d682ee&amp;itok=19zYDIOx" alt="Simron Singh at Sunnybrook Health Sciences Centre"> </div> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span>rahul.kalvapalle</span></span> <span class="field field--name-created field--type-created field--label-hidden"><time datetime="2024-07-02T09:45:10-04:00" title="Tuesday, July 2, 2024 - 09:45" class="datetime">Tue, 07/02/2024 - 09:45</time> </span> <div class="clearfix text-formatted field field--name-field-cutline-long field--type-text-long field--label-above"> <div class="field__label">Cutline</div> <div class="field__item"><p><em>Simron Singh, a medical oncologist at Sunnybrook Health Sciences Centre and associate professor in the Temerty Faculty of Medicine, led a study that found that radioligand therapy reduces the risk of advanced neuroendocrine tumour progression and death&nbsp;(photo by Kevin Van Paassen, Sunnybrook)</em></p> </div> </div> <div class="field field--name-field-topic field--type-entity-reference field--label-above"> <div class="field__label">Topic</div> <div class="field__item"><a href="/news/topics/breaking-research" hreflang="en">Breaking Research</a></div> </div> <div class="field field--name-field-story-tags field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><a href="/news/tags/department-medicine" hreflang="en">Department of Medicine</a></div> <div class="field__item"><a href="/taxonomy/term/6923" hreflang="en">Sunnybrook Health Sciences Centre</a></div> <div class="field__item"><a href="/news/tags/temerty-faculty-medicine" hreflang="en">Temerty Faculty of Medicine</a></div> <div class="field__item"><a href="/news/tags/cancer" hreflang="en">Cancer</a></div> </div> <div class="field field--name-field-subheadline field--type-string-long field--label-above"> <div class="field__label">Subheadline</div> <div class="field__item">Research led by scientists at Sunnybrook Health Sciences Centre and ֱ showed radioligand therapy to be an effective first-line treatment for advanced uncurable cancers<br> </div> </div> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>A novel approach for early cancer treatment known as radioligand therapy (RLT) has been shown to significantly reduce the risk of advanced neuroendocrine tumour progression and death, according to research led by scientists at Sunnybrook Health Sciences Centre and the University of Toronto.</p> <p>Results of the multi-centre clinical trial, which were <a href="https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)00701-3/abstract">published in&nbsp;<em>The Lancet</em></a>, provided evidence for the first time that RLT – when applied in the early stages after a patient’s diagnosis – slowed down the progression of aggressive grade 2 and 3 neuroendocrine tumours of the gastrointestinal tract.&nbsp;</p> <p>The treatment was shown to extend&nbsp;the average time of “progression-free survival” from approximately 8.5 months to 22.8 months.&nbsp;</p> <p>“This is the first study to show the effectiveness of RLT as the ‘first-line’ treatment with advanced uncurable cancer, or any cancer,” said the study’s global principal investigator <strong>Simron Singh</strong>, a medical oncologist at Sunnybrook and associate professor in the department of medicine at ֱ’s Temerty Faculty of Medicine. “This trial is groundbreaking not only for patients with neuroendocrine cancers, but for all cancer patients as it has implications for the practice of cancer treatment broadly.”</p> <p>Singh described RLT as a “game changer” in the treatment of cancer, which has traditionally been carried out by surgery, drugs or radiation. “While it’s technically radiation, it is given via a chemotherapy route through the blood until it reaches the precise location of the tumour,” said Singh, who is also an affiliate scientist at Sunnybrook Research Institute and co-founder of the&nbsp;Susan Leslie Clinic for Neuroendocrine Tumours&nbsp;at Sunnybrook’s Odette Cancer Centre.</p> <p>RLT involves injecting radioactive isotopes – in this case, the drug Lutathera&nbsp;– through an IV. This method targets&nbsp;<span style="font-family:&quot;Open Sans&quot;,sans-serif;mso-fareast-font-family: &quot;Times New Roman&quot;;color:#485667;mso-font-kerning:0pt;mso-ligatures:none">specific cancer cell receptors, delivering precise radiation to kill cancer cells while preserving healthy tissue.&nbsp;<o:p></o:p></span></p> <p>The study evaluated the use of RLT earlier as a first-line (or “up front”) treatment for patients newly diagnosed with grade 2 or 3 advanced gastrointestinal neuroendocrine tumours. Although neuroendocrine cancer is uncommon, incidence is rising rapidly, and few treatments exist for patients. This cancer is resistant to most therapies, making it challenging to treat.</p> <p>The results confirm the clinical benefit of earlier use of RLT for patients diagnosed with aggressive and life-threatening tumours, said Singh. “This is the next step in personalized targeted cancer therapy for patients, focused on more effectively killing cancer cells, while limiting the damage to surrounding healthy tissues.”</p> <p>Further investigations of RLT as a therapeutic option are ongoing to evaluate overall survival and long-term safety, which will better define next steps for how this therapy will change cancer treatment world-wide.</p> <p>The multi-site trial included investigators and participants from Canada, the United States, France, Germany, Italy, Netherlands, South Korea, Spain and the UK. An overview of the results was presented at the&nbsp;2024&nbsp;American Society of Clinical Oncology (ASCO) Gastrointestinal (GI) Cancers Symposium&nbsp;in January 2024.</p> </div> <div class="field field--name-field-news-home-page-banner field--type-boolean field--label-above"> <div class="field__label">News home page banner</div> <div class="field__item">Off</div> </div> <div class="field field--name-field-add-new-author-reporter field--type-entity-reference field--label-above"> <div class="field__label">Add new author/reporter</div> <div class="field__items"> <div class="field__item"><a href="/news/authors-reporters/nadia-radovini" hreflang="en">Nadia Radovini</a></div> </div> </div> Tue, 02 Jul 2024 13:45:10 +0000 rahul.kalvapalle 308154 at