茄子直播

茄子直播 researcher teams up with Toronto biotech firm to tackle treatment-resistant lung cancer

Photo of Igor Stagljar
The partnership brings together 茄子直播 researcher Igor Stagljar鈥檚 proprietary MaMTH Drug Screening (MaMTH-DS) technology with an artificial intelligence-powered platform developed by Toronto biotech firm Cyclica (photo by Sam Motala)

Igor Stagljar, a professor at the University of Toronto鈥檚 Donnelly Centre for Cellular and Biomolecular Research, and Toronto-based biotechnology company have launched a partnership to advance treatment of drug-resistant forms of lung cancer.

Together, they will identify small molecules that can inhibit the mutated epidermal growth factor receptor (EGFR), a protein whose normal function is frequently disrupted in non-small cell lung cancer.

The partnership brings together Stagljar鈥檚 proprietary MaMTH Drug Screening (MaMTH-DS) technology, developed in the Donnelly Centre and designed for the discovery of small molecule compounds capable of inactivating the triple mutant EGFR, with Cyclica鈥檚 MatchMaker artificial intelligence-powered platform, which will narrow down a shortlist of the most promising lead compounds identified by Stagljar鈥檚 lab.

Cyclica will then computationally optimize the molecular structures of the selected compounds for desired pharmacological properties before they are synthesized by Stagljar鈥檚 team, who will also test their efficacy in human cells.

鈥淲e are extremely pleased to be working with Cyclica since our collaboration represents a unique approach that unites two completely novel and complementary approaches 鈥 Cyclica鈥檚 artificial intelligence MatchMaker and our MaMTH-DS live-cell drug discovery assay 鈥 for the rapid identification and validation of novel EGFR inhibitors in non-small cell lung cancer,鈥 says Stagljar, who is also a professor in 茄子直播鈥檚 departments of biochemistry and molecular genetics in the Faculty of Medicine.

鈥淥ur joint efforts will accelerate our ability to build novel EGFR inhibitors with these cutting-edge technologies and will thus speed up their implementation in the clinic.鈥

Non-small cell lung cancer is the most common type of lung cancer, found in approximately 85 per cent of all lung cancer patients. Evolved drug resistance has been a key challenge for treating non-small cell lung cancer due to EGFR mutations, which are present in roughly 17 per cent of people with lung cancer in the United States. In patients of eastern Asian descent, the prevalence of these mutations increases to half. They are also more common in women than men.

Additional research in treating non-small cell lung cancer is critical to developing effective precision medicines that can target the evolving nature of the disease.

鈥淲e are thrilled to be working with the world-class Stagljar Lab to leverage our drug discovery platform to progress our shared interests in creating novel, advanced lead compounds for non-small cell lung cancer,鈥 says Naheed Kurji, Cyclica鈥檚 president and CEO.

鈥淭his project is an example of the growing integration between science and industry focused on commercialization, and a testament to the hyper-innovative work being done in our own backyard at the University of Toronto.鈥

All intellectual property generated from the project related to the compounds will be shared equally by 茄子直播 and Cyclica.

Donnelly Centre