茄子直播

(photo by Norman Wong)

One-of-a-kind web portal for rare disease research and treatment launches

茄子直播 expert co-leads international team behind project

A new web portal called PhenomeCentral is launching today to connect clinicians and scientists worldwide in an effort to speed the discovery of genes responsible for rare disorders. 

鈥淧henomeCentral securely stores clinical and genetic information on patients with undiagnosed rare diseases,鈥 said Michael Brudno, an associate professor with 茄子直播鈥檚 Department of Computer Science, who co-leads the project. Brudno is also the Canada Research Chair in Computational Biology and has an appointment in the Centre for Computational Medicine at the Hospital for Sick Children.

鈥淐linicians will upload information and the database will automatically and anonymously match patients with similar genome and phenotypes. This will enable faster diagnoses and simpler identification of the genetic cause of rare diseases,鈥 he said. 

More than 350 million people suffer from over 7,000 rare diseases worldwide and the genetic cause for at least half of these diseases is still unknown. According to the International Rare Disease Research Consortium (IRDiRC) there is a global push to identify genes for most genetic diseases by 2020 and PhenomeCentral represents a critical first step.

鈥淲e see patients affected by extremely rare or even new undescribed disorders. Having the ability to refer to cases with similar symptoms, anywhere in the world, is a critical step forward for rare disease research and seeing to the care of our patients,鈥 said William Gahl, director of the Undiagnosed Diseases Program at the National Institutes of Health (NIH) in Bethesda, Maryland.

Rare disease research is conducted in disparate centres all over the world, but the rarity of the conditions makes it imperative for researchers to collaborate in a timely and reliable way. 鈥淏eing able to 鈥榩lug in鈥 a tool like PhenomeCentral to our data-sharing platform means that we can make use of the power of its match-making abilities to find similar patients and advance research,鈥 said Hanns Lochm眉ller, coordinator of the EU-funded RD-Connect project.

鈥淐anada has already identified over 60 novel rare disease genes in the past two years,鈥 said Dr. Kym Boycott, co-lead of PhenomeCentral, geneticist and senior scientist at the Children鈥檚 Hospital of Eastern Ontario (CHEO). 鈥淧henomeCentral was born out of CARE for RARE which is a pan-Canadian research initiative that goes beyond identifying rare disease genes to develop treatments for better health outcomes. It鈥檚 exciting to see how the rest of the world is fully supporting PhenomeCentral and contributing data. Together, researchers around the world are going to successfully crack the code for thousands of patients with unsolved conditions.鈥

Global partners of PhenomeCentral include the NIH Undiagnosed Diseases Program in the United States, CARE for RARE Australia, Finding of Rare Disease Genes (Canada), RD-Connect (Europe and Australia), and the International Rare Disease Research Consortium.

PhenomeCentral is funded by the Canadian Institutes of Health Research (CIHR), Genome Canada, the Ontario Genomics Institute as well as the National Sciences and Engineering Research Council (NSERC) through the Collaborative Health Research Program.

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